PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Methyl 15-bromopentadecanoate
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2,5-Dioxopyrrolidin-1-yl 2-(2-(prop-2-yn-1-yloxy)ethoxy)acetate
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Fmoc-NH-CH2-PEG3-C2-NH2 hydrochloride
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4-(Triethylsilyl)but-3-yn-1-ol
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tert-Butyl 3-((4-formylphenyl)thio)azetidine-1-carboxylate
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N-Methyl-N'-(hydroxy-PEG2)-Cy5
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tert-Butyl (6-azaspiro[3.4]octan-2-yl)carbamate hydrochloride
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tert-Butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate
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2-Azaspiro[3.5]nonan-7-ol
![2-Azaspiro[3.5]nonan-7-ol](https://file.medchemexpress.com/product_pic/hy-w063561.gif "Click to View 2-Azaspiro[3.5]nonan-7-ol Product Detail")
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cis-3-(Methoxycarbonyl)cyclobutanecarboxylic acid
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4-(Aminomethyl)bicyclo[2.2.2]octane-1-carboxylic acid
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trans-Ethyl (1r,4r)-4-(aminomethyl)cyclohexane-1-carboxylate hydrochloride
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1-Ethyl trans-1,4-cyclohexanedicarboxylate
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Fmoc-C-PEG3-C3-Succinamic acid
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Bn-PEG2-Br
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3-(Cbz-aminomethyl)azetidine hydrochloride
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